Genomes
The advent of massively parallel sequencing technologies has made it possible for individual genomes to be sequenced to high levels of coverage. The pace of whole-genome sequencing is so rapid that this page is woefully out of date. I keep it up for historic reasons only!
| STUDY | SAMPLE | NGS | DEPTH | SNPS | NOVEL |
| Wheeler et al. 1 | Watson (Nobel laureate) | 454 | 7.4x | 3,322,093 | 606,797 |
| Ley et al. 2 | AML (Leukemia patient) | Illumina | 32.7x | 2,584,418* | 422,723 |
| Bentley et al. 3 | YRI (Yoruban male) | Illumina | 40.6x | 4,139,196 | 526,698 |
| Wang et al. 4 | CHB (Han Chinese) | Illumina | 36.0x | 3,074,097 | 417,016 |
| Ahn et al. 5 | SJK (Korean male) | Illumina | 28.95x | 3,439,107 | 420,083 |
| McKernan et al. 6 | YRI (Yoruban male) | SOLiD | 17.9x | 3,866,085 | 734,556 |
Note that another genome has also been sequenced, that of DNA sequencing pioneer J. Craig Venter, but the platform was traditional 3730 sequencing. I don’t expect to see another of those.
References
[1] Wheeler, D., et al. (2008). The complete genome of an individual by massively parallel DNA sequencing. Nature, 452 (7189), 872-876 DOI: 10.1038/nature06884
[2] Ley, T., Mardis, E., Ding, L., et al. (2008). DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature, 456 (7218), 66-72 DOI: 10.1038/nature07485
[3] Bentley, D., et al. (2008). Accurate whole human genome sequencing using reversible terminator chemistry. Nature, 456 (7218), 53-59 DOI: 10.1038/nature07517
[4] Wang, J., Wang, W., et al. (2008). The diploid genome sequence of an Asian individual. Nature, 456 (7218), 60-65 DOI: 10.1038/nature07484
[5] Ahn, S., et al. (2009). The first Korean genome sequence and analysis: Full genome sequencing for a socio-ethnic group. Genome Research DOI: 10.1101/gr.092197.109
[6] McKernan, K., et al. (2009). Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two base encoding Genome Research DOI: 10.1101/gr.091868.109
